Clinical evaluation of IAP (Immunosuppressive acidic protein) in the serum of patients with malignant tumors of head and neck--with special reference to prognosis and immunological parameters.

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The serum levels of IAP in patients with tumors of the head and neck were determined by single radial immunodiffusion. It was previously reported that the IAP level in these patients was commonly higher than normal. Statistical analysis of 58 patients revealed that the increase of IAP corresponded not only to the clinical stage of the tumor, but also to the probability of tumor recurrence. In addition, it was apparent that the IAP was significantly related to the PPD skin reaction representing delayed hypersensitivity and T-cell population capable of E-rosette formation.The evidence suggests that the determination of serum IAP is useful in understanding the immune defense of hosts against tumors.
耳鼻咽喉科臨床学会の論文