Three cases of so-called Mikulicz's disease.

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Three cases with so-called Mikulicz's disease were studied clinically. Case 1 A 35-year-old woman was suffering from bilateral lacrimal and submandibular gland swelling. Biopsy of the submandibular gland and lacrimal gland showed severe atrophy of the glandular tissue and extensive lympoid infiltration accompanied by germinal center. It is five years since she first came to our clinic and has remained generally well without any treatment. The swelling of the gland is naturally decreasing. Case 2 A 62-year-old man was suffering from bilateral lacrimal and submandibular gland diffuse swelling. Histological examination revealed extensive infiltration with lymphocytes and plasma cells. Five months after his first visit, he showed significant changes in clinical and laboratory findings, that is to say, general lymphnode swelling, total protein 9.8 g/dl, hyper gamma globulinemia 50.1%, elevated ESR 119 mm/hr, etc. Steroid treatment resulted in gradual disappearance of the swelling. Case 3 A 69-year-old woman was referred to our clinic for evaluation regarding the enlargement of bilateral parotid gland, submandibular gland, right orbital region and submental lymphnode. This is a case of 45 years' duration and for a long time was treated as sarcoma. Steroid treatment resulted in gradual disappearance of the swelling.
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