EFFECT OF ASCORBIC ACID, RIBOFLAVIN OR CHOLINE ON THE PRODUCTION OF HYPERTENSION IN THE RAT FED A DIET RICH IN SODIUM CHLORIDE

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1. An arterial hypertension was developed in the rat fed a diet containing 3.5per cent sodium chloride for a period of 27 weeks and this hypertension was found to be accompanied by hypertrophy of the kidneys and adrenals, an increased excretion of urinary 17-ketosteroids, an elevated serum cholesterol level, a reduced activity of succinoxidase and a decrease in riboflavin level of the kidneys. On the contrary, no changes in succinoxidase activity and ascorbic acid level of the liver were observed.2. An elevation of the blood pressure, a hypertrophy of the kidneys and adrenals, an increase in the urinary 17-ketosteroids and a decrease in the renal succinoxidase activity in the rats were somewhat prevented by a previous addition of ascorbic acid, riboflavin or choline to the diet.3. The addition of riboflavin was effective to prevent an elevation of the blood pressure and the serum cholesterol level.4. Significant histological changes were observed in the kidneys of the rats fed a salt-rich diet. The administrations of ascorbic acid, riboflavin or choline protected the histological changes induced by high-salt diet to a certain extent.
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