GONADOTROPIC ACTIVITY IN POOLED URINE WITH ACIDIFICATION

概要

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Since a gonadotropin-inhibiting substance in human urine is precipitated by acidification of urine, comparisons of the gonadotropic activities and the inhibitory effects in urine after acidification and removal of precipitate and in untreated urine were carried out in bioassays. Gonadotropic activity in the supernatantof acidified urine, in which a gonadotropin-inhibitor was removed through precipitation, was somewhat higher than that in non-acidified urine in the ovulation method. Inhibition on ovulation was obtained in the rats injected the heated extract taken from the non-acidified urine, while no inhibition was obtained in those given that taken from the supernatant of acidified urine. These findings suggest that there is a possibility that the assayed gonadotropic activity of urine without acidification by certain methods is slightly lower than the actual activity by the presence of the inhibitor.
社団法人日本内分泌学会の論文