Effect of Gonadotropins on the Reduced Excretion of a Gonadotropin-Inhibiting Substance in the Hypophysectomized Rats

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A gonadotropin-inhibiting substance, which is assumed to be secreted by the pineal, is significantly reduced in urine following the removal of the pituitary in rats. The experiment was performed to investigate whether the reduced excretion of the gonadotropin-inhibiting substance in hypophysectomized rats is restored by administration of gonadotropins and whether the excretion of the inhibitor is influenced by administration of gonadotropins in intact animals. Administration of gonadotropins was effective in partial restoration of the reduced excretion of the inhibitor in the hypophysectomized rats. Treatment of gonadotropins in intact rats had no effect on the excretion of the inhibitor. These findings suggest that gonadotropins play some role in the production of the inhibitor.
社団法人日本内分泌学会の論文