A Role of Sialic Acid in the Crude Urinary Extract of a Gonadotropin-Inhibiting Substance

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Chemical analyses of protein, pentose, hexose and sialic acid in the crude human urinary extracts prepared from the non-acidified urine (NA), the supernatant of the acidified urine (SA) and the precipitate of the acidified urine (PPT) revealed a high content of sialic acids in Samples NA and PPT, both of which exert an inhibitory effect on human chorionic gonadotropin, compared with Sample SA which does not show inhibition.<BR>A role of sialic acids in inhibition was, therefore, studied by the ovulation test and the ovarian ascorbic acid depletion assay. No differences were found in the inhibitory effect between Sample NA and hydrolyzed NA, and between Sample PPT and hydrolyzed PPT. The dialysate of the hydrolyzed NA or PPT did not show any inhibitory activity. The evidence suggests that the activity of a gonadotropin inhibitor is not accounted for by the presence of sialic acid.
社団法人日本内分泌学会の論文