:Hu-IFN-β (1)

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A 8-year-old boy suffering from a pathologic fracture of his right humeral shaft, visited to our clinic on 15 MAY, 1980. His clinical diagnosis was suspected as a Ewing's Sarcoma and he had to get open biopsy which showed Ewing's Sarcoma histologically. As an amputation surgery was refused, immediately Adriamycin was given and radiation therapy was started.On 3 months after these initial therapies, X-ray findings showed sclerotic changes. However, 1 year after the biopsy, a radiolucent area on the right humerus which was made by the biopsy was bigan to enlarge with secondary pathologic fracture. And so, recurrence of the tumor was suspected firmly. Disarticulation of the right glenohumeral joint was done. However, histological study showed no recurrence.After disarticulation IFN-β was given intravenously since July, 1981 to 113, 000, 000 I. U totally on MAY, 1982. The side effect of IFN-β was high fever which was disappeared by medication.2 yeas after the biopsy, he is living in high spirit without any metastases.
西日本整形・災害外科学会の論文