EHDP treatment of Paget's disease.

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Monostotic paget's disease involving the entire right pelvis was encountered. The therapeutic effect of EHDP is described together with literature reviews.The patient was a 51-year-old man with an elevated Al-p level and mild dull pain in the right pelvis. Despite treatment with pig calcitonin from Apr, 1981, the Al-p level that had once been controlled began to reelevate. The treatment was changed to eel calcitonin, but as this again resulted in reelevation of Al-p after a temporary reduction, administration of eel calcitonin was suspended. In Feb, 1985, Al-p and urinary hydroxyproline rose to 46.5 (K. A. U.) and 101mg/day respectivery with growth of dull pain in the lesion. As we had access to EHDP, oral administration of 400mg/ day (6.3mg/kg) was begun from Feb, 1985. From 2 months after EHDP therapy, it improved Al-p, normalized urinary hydroxyproline and remitted local pain. Although administration was suspended after 6 months (end of Aug) for fear of its adverse effect on bone metabolism, Al-p showed a tendency of gradual decrease (18.9 K. A. U.) even one month after suspension.
西日本整形・災害外科学会の論文