Clinicopathologic Analyses and Therapeutic Results of Low-grade Chondrosarcomas.

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Clinicopathologic analyses and therapeutic results of ten low-grade chondrosarcomas (Grade I) are presented. Seven patients were managed with a wide en bloc resection, two patients with an en bloc resection, and one with curettage. The duration of follow-up ranged from two to eleven years, with a mean of six years. Two chondrosarcomas recurred locally, a repeat excision was done, and finally the patients died eleven years after initial surgery. Radiographic findings of low-grade chondrosarcomas characteristically demonstrated an expanded and destroyed cortex. All ten tumors were studied immunohistochemically by using α1-antitrypsin (AT), α1-antichymotrypsin (ACT), and S-100. The results indicate that AT and ACT may not be useful indicators of malignancy. Diagnosis based not only on histologic but also radiographic findings may be needed in low-grade chondrosarcoma.