INH・RFP併用治療中にみられた急性肝障害の1例

概要

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A 62 years old male who suffered from acute hepatitis soon after starting the treatment with isoniazid, ethambutol and rifampicin for pulmonary tuberculosis was reported.<BR>For 2 weeks before admission, isoniazid and ethambutol were given without any abnormal sign, butassoon as rifampicin was added after admission, thepatient suffered from nausea, loss of appetite, vomiting and headache, and thereafterjaundice and coma appeared with serum transaminase level up to 900 units.<BR>When isoniazid was resumed after his recovery, liver function again became abnormal. However as regimen of rifampicin associated with ethambutol was resumed, no manifestation of hepato toxicity was seen at all.<BR>Abnormality of liver function was more freqeuntly found in cases treated with rifampicin plus isoniazid than in cases with rifampicin plus drugs other than isoniazid.<BR>Disturhance of liver function under treatment with isoniazid and rifampicin was discussed.
日本結核病学会の論文