糖尿病を合併した肺結核患者における細胞性免疫能の検討

概要

論文の詳細を見る
Cell mediated immune responsiveness was studied in tuberculosis patients with diabetes mellitus. Peripheral blood lymphocytes (PBL) were examined for their in vitro proliferative response stimulated with purified protein derivative of tuberculin (PPD) or nonspecifically with PHA or Con A. PBL was also examined for PPD-induced mitogenic factor (MF) production and/or their responsiveness to MF stimulation. The results obtained were: 1) PBL from tuberculosis patients with (P<0.01) or without (P<0.02) diabetes mellitus gave lower proliferative response to Con A stimulation than PBL from healthy, tuberculin-positive individuals. 2) PBL from tuberculosis patients with diabetes mellitus showed decreased proliferative re sponse to PPD stimulation compared with PBL from either patients without diabetes mellitus or healthy donors. 3) No significant differences were observed between patients with and without diabetes mel litus or between patients and healthy donors in their ability of PPD-stimulated production of MF or response to MF which was elaborated by BCG stimulation of pleural fluid lymphocytes, although PBL from tuberculosis patients responded slightly less than PBL from healthy donors to MF stimulation. Decreased response to PPD stimulation observed with lymphocytes of patients with diabetes mellitus suggests depressed cell mediated immunity to tuberculosis in these patients.
日本結核病学会の論文