Interaction of 1.ALPHA.,24-dihydroxyvitamin D3 with the chick intestinal 1.ALPHA.,25-dihydroxyvitamin D3 receptor system.
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概要
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The interaction of 1α, 24-dihydroxyvitamin D3 with the 1α, 25-dihydroxyvitamin D3 receptor system was studied in chick intestinal mucosa. The competitive receptor binding assay indicated that 1α, 24-dihydroxy-vitamin D3 bound to a cytosol 1α, 25-dihydroxyvitamin D3 receptor with a relatively high affinity compared with other vitamin D3 analogs. The R-isomer of 1α, 24-dihydroxyvitamin D3 revealed higher affinity for the receptor than the S-isomer. In the reconstituted cytosol-chromatin system, both 1α, 24(R)-dihydroxy-[3H]-vitamin D3 and 1α, 24(S)-dihydroxy-[3H]-vitamin D3 specifically associated with chromatin via a temperature-dependent process. The association of 1α, 24-dihydroxy-[3H]-vitamin D3 with chromatin was reduced in the presence of competing unlabeled 1α, 25-dihydroxyvitamin D3. Furthermore, the chromatin-associated 1α, 24-dihydroxy-[3H]-vitamin D3 was dissociated by a high concentration of KCl, likewise 1α, 25-dihydroxy-[3H]-vitamin D3. From these results, it is strongly indicated that 1α, 24-dihydroxyvitamin D3 is recognized by cytosol 1α, 25-dihydroxyvitamin D3 receptor as an analog of 1α, 25-dihydroxyvitamin D3 and associates with chromatin by the same mechanism as 1α, 25-dihydroxyvitamin D3.
- 財団法人 学会誌刊行センターの論文
著者
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細谷 憲政
Department of Nutrition, School of Health Sciences, Faculty of Medicine, University of Tokyo
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志村 二三夫
Department of Nutrition, School of Health Sciences, Faculty of Medicine, University of Tokyo
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森内 幸子
Department of Food and Nutrition, Faculty of Home Economics, Japan Women's University
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森内 幸子
Department of Food and Nutrition, School of Home Economics, Japan Women's University
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細谷 憲政
Department fo Nutrition, School of Health Sciences, Faculty of Medicine, University of Tokyo
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