Inhibition of .BETA.-sitosterol on intestinal cholesterol absorption in rat using in vivo dual isotope ratio method.
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概要
- 論文の詳細を見る
The inhibitory effects of β-sitosterol on intestinal cholesterol absorption were studied by means of a dual isotope plasma ratio method (in vivo), which is a new technique for the measurement of cholesterol absorption, as well as a ligated-loop method (in situ). The results obtained were as follows: 1. The absorption of β-sitosterol itself was significantly less than cholesterol. Cholesterol was selectively absorbed from rat intestine. 2. When 100 to 1, 000μg of β-sitosterol were added to the dose solution containing 10μg of cholesterol, cholesterol absorption by the in vivo experiment decreased with the increase of additional β-sitosterol. 3. A similar inhibitory effect of β-sitosterol was observed by the in situ ligated-loop method. These results suggest that β-sitosterol actually inhibits cholesterol absorption in the physiological state of an animal.
- 財団法人 学会誌刊行センターの論文
著者
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渡部 誠
Department of Nutrition, School of Health Sciences, Faculty of Medicine, University of Tokyo
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奥 恒行
Department of Nutrition, School of Health Sciences, Faculty of Medicine, University of Tokyo
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四童子 好広
Department of Nutrition, School of Health Sciences, Faculty of Medicine, University of Tokyo
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奥 恒行
Department of Nutrition, School of Health Sciences, Faculty fo Medicine, University of Toktyo
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武藤 泰敏
Department of Medicine, GU u University, School of Medicine
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細谷 憲政
Department fo Nutrition, School of Health Sciences, Faculty of Medicine, University of Tokyo
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四童子 好広
Department of Biochemistry and Nutrition School of Health Sciences, Faculty of Medicine, University of Tokyo
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奥 恒行
Department of Nutrition, Faculty of Medicine. The University of Tokyo
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