Effects of Dexamethasone on Experimental Atherosclerosis in Cholesterol-fed Rabbits.

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• We studied the effects of a synthetic adrenocortical steroid, dexamethasone, on the development of experimental atherosclerosis in cholesterol-fed rabbits. Daily intramuscular injection of dexamethasone (0.125mg/day) remarkably inhibited the aortic atherosclerosis induced by feeding a 1% cholesterol-rich diet for 8 weeks, although it aggravated diet-induced hyperlipidemia. Histologically, less foam cell accumulation was observed in the atherosclerotic lesions of the dexamethasone-treated rabbits as compared with the control animals. When rabbits were fed a normal chow diet for 10 weeks after receiving the 1% cholesterol-rich diet for 8 weeks, no regression of atherosclerotic lesions was observed with the daily injection of dexamethasone (0.125mg/day); however, the drug again tended to inhibit further progression of atherosclerosis. The anti-atherogenic mechanism of dexamethasone may involve an inhibition of recruitment of blood monocytes and the insudation of atherogenic lipoproteins, mainly β-very low density lipoprotein (β-VLDL) in the present experiments, into the aortic intima, or it may involve a change in the size and structure of the lipoproteins, resulting in their decreased passage through the aortic endothelium into the intima.

• 財団法人 学会誌刊行センターの論文

著者

• Yamada Kazuyoshi

  Department Of Geriatrics Narita Memorial Hospital

• Asai Kanichi

  Department Of Geriatrics Nagoya University School Of Medicine

• Funaki Chiaki

  Department Of Geriatrics Nagoya University School Of Medicine

• Naito Michitaka

  Department Of Geriatric Medicine Nagoya University School Of Medicine

• Yoshimine Noboru

  Department Of Geriatrics Nagoya University School Of Medicine

• Hayashi Toshio

  Department Of Bioldgy College Of General Education University Of Tokyo Komaba

• Kuzuya Masafumi

  Department Of Community Healthcare And Geriatrics Nagoya University Graduate School Of Medicine

• KUZUYA Masafumi

  Department of Geriatrics, Nagoya University School of Medicine

• YASUE Masahiro

  Department of Geriatrics, Nagoya University School of Medicine

• HAYASHI Toshio

  Department of Geriatrics, Nagoya University School of Medicine

• KUZUYA Masafumi

  Department of Community Healthcare & Geriatrics, Nagoya University Graduate School of Medicine

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