Metabolism of Orally Adiministered Ergosterol and 7-Dehydrocholesterol in Rats and Lack of Evidence for Their Vitamin D Biological Activity.
スポンサーリンク
概要
- 論文の詳細を見る
Metabolism of orally administered ergosterol (Erg) and 7-dehydrocholesterol (7-DHC) in rats and their vitamin D biological activity were investigated. Most of orally administered Erg and 7-DHC were excreted in feces and the remaining sterols were absorbed through intestine. The absorbed sterols were not transported in skin as the intact forms but metabolized into brassicasterol and cholesterol, respectively, within 25h. Neither increment of intestinal calcium absorption nor plasma calcium concentrations were observed by oral administration of Erg and 7-DHC to vitamin D-deficient rats. Therefore, we have concluded that orally administered Erg and 7-DHC have no vitamin D biological activity.
- 財団法人 学会誌刊行センターの論文
著者
-
Okano Toshio
Department Of Hygienic Science Kobe Pharmaceutical University
-
Kobayashi Tadashi
Department Of Cardiology Aichi Medical University
-
Tsugawa Naoko
Department Of Hygienic Sciences Kobe Pharmaceutical University
-
Takeuchi Atsuko
Department Of Gastroenterology Kitasato University School Of Medicine
-
TAKEUCHI Atsuko
Department of Hygienic Sciences, Kobe Women's College of Pharmacy
-
TSUGAWA Naoko
Department of Hygienic Sciences, Kobe Women's College of Pharmacy
-
KAYAMA Mayumi
Department of Hygienic Sciences, Kobe Women's College of Pharmacy
-
OKANO Toshio
Department of Hygienic Sciences, Kobe Women's College of Pharmacy
-
KOBAYASHI Tadashi
Department of Hygienic Sciences, Kobe Women's College of Pharmacy
-
KAYAMA Mayumi
Department of Hygienic Sciences, Kobe Women's College of Pharmacy
関連論文
- 2-I-19 思春期男女のビタミンDおよびカルシウム栄養と骨密度に関する5年間の追跡調査(一般演題,日本ビタミン学会第62回大会発表要旨)
- Improvement of Vitamin D Status in Japanese Institutionalized Elderly by Supplementation with 800 IU of Vitamin D_3
- Synthetic Studies of Vitamin D Analogs. XXII.Synthesis and Antiproliferation Activity of Putative Metabolites of 1α, 25-Dihydroxy-22-oxavitamin D_3
- Low plasma phylloquinone concentration is associated with high incidence of vertebral fracture in Japanese women
- Vitamin K Content of Foods and Dietary Vitamin K Intake in Japanese Young Women
- Nutritional Effects of γ-Glutamyl Carboxylase Gene Polymorphism on the Correlation between the Vitamin K Status and γ-Carboxylation of Osteocalcin in Young Males
- Determination of Fat-Soluble Vitamins in Human Plasma, Breast Milk and Food Samples : Application in Nutrition Survey for Establishment of "Dietary Reference Intakes for Japanese"
- The improvement of quality od life after catheter ablation
- Local Drug Delivery of an Antitumor Lipid a Analog Inhibits Neointimal Hyperplasia in Dogs
- Magnetization Process of Exchange-Coupled Ferrimagnetic Double-Layered Films
- Synthesis of γ-Hydroxybutenolides Applying Crossed Aldol Condensation in the Presence of a Bulky Lewis Acid and Their Anti-tumor Activity
- Antitumoral Activity of 13-Demethyl or 13-Substituted Analogues of All-trans Retinoic Acid and 9-cis Retinoic Acid in the Human Myeloid Leukemia Cell Line HL-60(Biochemistry)
- Scanning Tunneling Microscopy Study of the c(4X4) Structure Formation in the Sub-Monolayer Sb/Si(100) System : Surfaces, Interfaces, and Films
- Mg/Si(100) Reconstructions Studied by Scanning Tunneling Microscopy
- High energy electron observation by Polar Patrol Balloon flight in Antarctica
- Isolation, Identification and Biological Activity of 24R,25-Dihydroxy-3-epi-vitamin D_3 : A Novel Metabolite of 24R, 25-Dihydroxyvitamin D_3 Produced in Rat Osteosarcoma Cells (UMR 106)
- Biological Activities of 2α-Substituted Analogues of 1α, 25-Dihydroxyvitamin D_3 in Transcriptional Regulation and Human Promyelocytic Leukemia (HL-60) Cell Proliferation and Differentiation(Medicinal Chemistry)
- Synthesis and Biological Evaluation of 9Z-Retinoic Acid Analogs Having 2-Substituted Benzo[b]furan
- Characterization of 3-Epi-1α, 25-dihydroxyvitamin D_3 Involved in 1α, 25-Dihydroxyvitamin D_3 Metabolic Pathway in Cultured Cell Lines
- In Vitro Biological Activities of a Series of 2β-Substituted Analogues of 1α, 25-Dihydroxyvitamin D_3
- Rapid Control of Transmembrane Calcium Influx by 1α, 25-Dihydroxyvitamin D_3 and Its Analogues in Rat Osteoblast-Like Cells
- Singly Dehydroxylated A-Ring Analogues of 19-Nor-1α, 25-dihydroxyvitamin D_3 and 19-Nor-22-oxa-1α, 25-dihydroxyvitamin D_3 : Novel Vitamin D_3 Analogues with Potent Transcriptional Activity but Extremely Low Affinity for Vitamin D Receptor
- Synthetic Studies of Vitamin D Analogs. XXIV. Synthesis of Active Vitamin D_3 Analogs Substituted at the 2β-Position and Their Preventive Effects on Bone Mineral Loss in Ovariectomized Rats
- Temperature Dependence of Interface Wall Energy in Exchange-Coupled Triple-Layered Films
- Magnetoresistance Effect of Co/AlO_x/NiFe/AU/n-Si Diode Structure
- Synthesis, Crystal Structure and Magnetic Properties of Iron Particles Encaged in Carbon Nanocapsules
- Magnetic Anisotropy of Co/Pt Multilayers Evaporated on NaCl(100) Substrates
- Coercivity Enhancement in Co-Pt Alloy Films due to Annealing in Air
- Interpretation of Perpendicular Magnetic Anisotropy in Transition Metal/Noble Metal Superlattice Films in Terms of Pair Model
- Tilted Uniaxial Magnetic Anisotropy in Sputtered TbFeCo Films
- Magnetostatic Uniaxial Anisotropy in Metal Magnetic Tape
- Effect of Annealing on Magnetic Properties of Sputtered CoPt Alloy Films
- Dependence of Magnetic Properties of Co/Pt Multilayers on Deposition Temperature of Pt Buffer Layers
- Magnetic Properties of CoPt Alloy Films Sputtered on Pt Underlayers
- Magnetic Properties and Structure of Co/Pt Multilayered Films Evaporated on Heated Substrates
- Histologic Breast Cancer Extent after Neoadjuvant Chemotherapy : Comparison with Multidetector-row CT and Dynamic MRI
- Silver-Induced 3 × 3 Phase on 6H-SiC(0001)√ × √ Surface
- Simplified method for the determination of 25-hydroxy and 1α,25-dihydroxy metabolites of vitamins D_2 and D_3 in human plasma Application to nutritional studies
- A SENSITIVE METHOD FOR THE DETERMINATION OF 1,25-DIHYDROXYVITAMIN D IN PLASMA BY USING CALF THYMUS RECEPTOR
- Determination of Vitamin D2,D3 and their Metabolites in Plasma
- DETERMINATION OF VITAMIN D AND ITS METABOLITES IN BREAST AND COW'S MILK
- 25-HYDROXYVITAMIN D_3 BINDING PROTEIN IN RAT LYMPH
- Use of Tea or Coffee Lees as Adsorbent for Removal of Benzene from Wastewater
- Influence of Oversizing Stent Implantation on Late Restenosis in Small Coronary Vessels
- Can Serum Level of Lipocalin-type Prostaglandin D Synthase (L-PGDS) Be a Predictor of Coronary Atherosclerosis? : An Intracoronary Ultrasound (ICUS) Study
- Quantitative Coronary Angiographic (QCA) and Intracoronary Ultrasound (ICUS) Predictors of In-Stent Restenosis (ISR) Following ICUS Guided Stenting in Small Vessels
- Peri-Stent Remodeling and In-Stent Restenosis in Different Stent Designs Assessed by 3D Intracoronary Ultrasound (ICUS)
- Effect of Spherosomes on Control of Aphis gossypii Glover in Cucumbers Using Imidacloprid
- Effects of Spherosomes on Degradation of Pretilachlor and Esprocarb in Soil
- Three-year Follow-up After Intracoronary Ultrasound (ICUS) Guided Aggressive "Stent-Like" Balloon Angioplasty (BA) in Comparison with Stent Implantation
- Utilization of Rice Bran to Prevent Bulking in the Activated Sludge Process
- Efficiency of Rice Bran for Removal of p-Dichlorobenzene from Water
- The predictive value of PgR and HER-2 for response to primary systemic chemotherapy in inflammatory breast cancer
- Determination of plasma Vitamin K by high-performance liquid chromatography with fluorescence detection using Vitamin K analogs as internal standards
- Absorption of Calcium, Magnesium, Phosphorus, Iron and Zinc in Growing Male Rats Fed Diets Containing either Phytate-free Soybean Protein or Soybean Protein Isolate or Casein
- Intestinal absorption of calcium from calcium ascorbate in rats
- Selective Inhibition of Mammalian DNA Polymerase α by Vitamin D_2 and D_3
- Abstracts from the 43rd Kansai Calcium Conference October 16, 1999 Osaka Ohbayashi Bldg., Osaka, Japan
- Effects of a Fermented Vegetable Product on Fat Deposition and Bone Metabolism in Ovariectomized Rats
- The incidence of glucose intolerance in 406 patients with obstructive sleep apnea-hypopnea syndrome
- Bioavailability of Calcium from Calcium Carbonate, DL-Calcium Lactate, L-Calcium Lactate and Powdered Oyster Shell Calcium in Vitamin D-Deficient or -Replete Rats
- The impact of lifestyle factors on serum 25-hydroxyvitamin D levels : a cross-sectional study in Japanese women aged 19-25 years
- Long-term hospitalization during pregnancy is a risk factor for vitamin D deficiency in neonates
- Novel Metabolic Pathways of Vitamin D_3 : Identification of C-3 Epimerization and C-25 Dehydration Pathways and Biological Activity of Novel Metabolites
- Subacute Vanadium Toxicity in Rats
- Effect of vitamin D supplementation in the institutionalized elderly
- Primary Rhabdomyosarcoma of the Breast in a 13-Year-Old Girl : Report of a Case
- Atomic Force Microscopy Observation of Ferroelastic Domain Boundary in GdP_5O_
- Structure and Dynamics of Chlorocyclohexane/Thiourea Inclusion Compound C_6H_Cl/SC(NH_2)_2 Studied by X-ray Diffraction and ^1H-NMR(Condensed Matter : Structure, Mechanical and Thermal Properties)
- Investigation of Ferroelastic Domain Boundary Structures of MP_5O_ (M: La-Tb) and LaNbO_4 by Means of Scanning Tunneling Microscope, Atomic Force Microscope, X-Ray and Neutron Diffraction Analyses
- Observations of the Ferroelastic Domain Structure of MP_5O_ (M:La-Tb) by means of Scanning Tunneling Microscope, Electron Spin Resonance and X-Ray Diffraction
- Studies on Removal Efficiency of Rice Bran for Pesticides
- The Electron Paramagnetic Resonance of K_2SeO_4
- Quantification of fat-soluble vitamins in human breast milk by liquid chromatography-tandem mass spectrometry
- Dielectric and Thermal Study of K_2SeO_4 Transitions
- High level of serum undercarboxylated osteocalcin in patients with incident fractures during bisphosphonate treatment
- Efficiency of Rice Bran for the Removal of Fe^ from Solution
- Vitamin D insufficiency defined by serum 25-hydroxyvitamin D and parathyroid hormone before and after oral vitamin D_3 load in Japanese subjects
- Pesticide Residue Reduction in Selected Vegetables Using Rice-Bran
- Decomposition of Monochioramine from Water with Rice Bran
- Effects of Bisphenol A and Nonylphenol on Proliferation and Expression of Estrogen Receptor mRNA in Osteogenic Osteosarcoma MG-63 Cells(PROCEEDINGS OF 24TH SYMPOSIUM ON TOXICOLOGY AND ENVIRONMENTAL HEALTH)
- Generation of Cyanide Ion by the Reaction of Hexamine and Losartan Potassium with Sodium Hypochlorite
- Biological Activity Profiles of 1α, 25-Dihydroxyvitamin D_2,D_3,D_4,D_7,and 24-Epi-1α, 25-dihydroxyvitamin D_2
- Isolation, Identification and Biological Activity of 24R,25-Dihydroxy-3-epi-vitamin D_3 : A Novel Metabolite of 24R, 25-Dihydroxyvitamin D_3 Produced in Rat Osteosarcoma Cells (UMR 106)
- Effects of Uniaxial Stress and Electric Field on Paramagnetic Spectra of Cr^ in KH_2PO_4
- Determination of Anionic Surfactants in Water by Atomic Absorption Spectrophotometry (Regular Presentations) (Proceedings of the 8th Symposium on Environmental Pollutants and Toxicology)
- ASSAY OF METALS IN SLUDGE PRODUCED WITH A TREATING APPARATUS FOR WASTE WATER DISCHARGED FROM CHEMICAL LABORATORIES
- Pyroelectricity in Solid Hydrogen Chloride
- Atomic Absorption Spectrophotometric Determination of Nonionic Surfactants in Water (Regular Presentations) (Proceedings of the 9th Symposium on Environmental Pollutants and Toxicology)
- Nutritional aspects of vitamin D and its metabolites in Japanese children and adults
- Electron Paramagnetic Resonance Study of Potassium Di-Hydrogen Phosphate Doped with Cr^ Ions
- Dependence of Hot Electron Transport on Base Layer Thickness of Magnetic Tunnel Transistor
- Absorbability of Calcium from a New Calcium Supplement Prepared from Bovine Marrow-Free Bone in Rats.
- Dielectric Dispersion in Ni-Doped KTaO3
- Dietary Reference Intakes for Japanese 2010: Fat-Soluble Vitamins
- Metabolism of Orally Adiministered Ergosterol and 7-Dehydrocholesterol in Rats and Lack of Evidence for Their Vitamin D Biological Activity.
- Gross and Separative Determination of 1.ALPHA.,25-Dihydroxyvitamin D2 and D3 in Plasma Using Calf Thymus Receptor.
- Preparation, 1,3-dipolar cycloaddition, and thermal and photochemical reactions of 3,5-exo- and 3,5-endo-7-methylene-4-azateracyclo[4.2.1.0.2,803,5]nona-9-ones.
- Studies of 8-quinolinethiol as chelating agents. III. Distribution behavior of 8-quinolinethiol between chloroform and aqueous solutions.
- Possible clinical cure of metastatic breast cancer : lessons from our 30-year experience with oligometastatic breast cancer patients and literature review