線維性骨異形成症の骨肉腫転化例に奏効したMTX大量療法と併用化学療法

概要

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Combination chemotherapy was effectively used after the surgical operation of a case of 30-year-old female with osteosarcoma arising in a fibrous dysplasia of the left mandible. In this case, a high dose methotrexate (MTX 12g/“cours”) with citrovorum (CF) rescue was administered mainly by six “cours”, in combination with several chemotherapeutics, such as Adriamycin (50-70 mg), Endoxan (EX 800-1, 000 mg) Vincristine (VCR 2.5 mg), resulting in total dose of 72 g, 490 mg, 6, 900 mg and 19 mg, respectively. This therapy has probably been very effective, because a possibility of recurrence was strongly considered from the viewpoints of a relapse after the first operation and the clinical findings during the second surgery.<BR>Side effects of the chemotherapy were relatively mild and temporary.<BR>No relapse has been observed in the last two years after the treatment.<BR>It was proved that this chemotherapy was applicable with safety and very effective for the treatment of osteosarcoma provided that the cases are chosen and put under supportive medical care.<BR>In this paper, an administration method of such chemotherapeutics is described.