The relation of ras oncogene product p21 expression to clinical tumor status and prognosis in human oral squamous cell carcinomas.

概要

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The expression of ras oncogene p21 (p21ras) in the biopsy or operation materials derived from 34 oral squamous cell carcinomas, 33 oral leukoplakias and 10 normal oral mucosae was investigated by the avidin-biotin-peroxidase complex (ABC) method described by Hsu et al. In the current study, the sheep antiserum raised against RasHa p21 and rat monoclonal antibody to p21ras, Y 13-259, were used. The expression of p21ras was found in 17 cases of the 34 oral squamous cell carcinomas examined although all of the examined oral leukoplakias and normal oral mucosae did not show positive staining for p21ras. When the expression of p21ras in oral squamous cell carcinomas was related to clinical tumor status and prognosis, 10 of the 17 cases showing positive staining for p21ras had poor prognosis. The cases with the tumor containing p21ras had significantly poor prognosis compared with cases without p21ras (p<0.005). Moreover, in the cases with the tumor classified grade III according to the classification system of squamous cell carcinoma proposed by WHO, the expression of p21ras was intimately associated with poor prognosis.
社団法人日本口腔外科学会の論文