Expression of ras oncogene product p21 in maxillary cancer tissues.

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Activation of the cellular oncogene ras may be an important event on tumorigenesis in many types of human malignancies. In the present study, expression of the ras oncogene product p21 (p21ras) in fresh tumor tissue from a squamous cell carcinoma of the maxillary sinus was examined by immunoperoxidase staining and immunoblotting. The tissue sections from biopsy material taken at pretreatment time were found to show intensively positive staining for rabbit antiserum or monoclonal antibody raised against p21ras However, the amount of p21ras present in the tumor tissues obtained from the primary site immediately after completion of cancer treatment including intra-arterial infusion of cisplatin (75 mg) into a superficial temporal artery and chemoimmunotherapy (UFT: 11.2 g, OK-432: 26.5 KE), was markedly decreased, when compared with the biopsy material. These findings led us to suggest that the expression of ras oncogene is intimately associated with occurrence of the maxillary cancer reported here and is modified by some cancer therapy.
社団法人日本口腔外科学会の論文