Dermititis caused by zinc deficiency during total parenteral nutrition.

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This paper reports a case of dermatitis which was caused by zinc deficiency during total parenteral nutrition (TPN). A 61-year-old male with hemiplegia and dyslalia induced by cerebral hemorrhage developed carcinoma of the maxillary sinus. In spite of intensive cancer therapy, the tumor continued to grow and gradually destroy the tissue of the orofacial area. Since he had dysphagia due to the orofacial tissue defect in addition to hemiplegia and his nutritional state deteriorated, We started TPN. Although TPN improved his poor nutritional state, skin rash and erosion appeared on the face, extremities and perineum about 42 days after starting TPN. The patient's clinical symptoms and the low concentrations of trace elements in blood led us to suspect dermatitis due to trace element deficiency. We started to administer a preparation containing the essential trace-elements intravenously. Consequently, the dermatitis disappeared rapidly and the concentrations of trace elements, particularly zinc, entered the normal range. Therefore, in this case zinc deficiency during TPN most likely caused dermatitis which was cured by the administration of a preparation containing essential trace elements including zinc.
社団法人日本口腔外科学会の論文