The effects of combined treatment with radiation and bleomycin on the oral carcinoma involving the mandible.

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The effect of concurrent combined treatment with 22.5 Gy of radiation and 110 mg of bleomycin or 55mg of peplomycin on oral carcinoma involving the mandible was examined histologically.<BR>In 14 of 18 patients who had mandibles resected after this combined treatment, bone invasion by carcinoma was observed histologically. According to Shimosato's classification of histological effects, 3 belonged to Grade III/IV, 4 to II b, 3 to II a and 4 to I. The formation of new bone that was considered to be reparable was observed in the marked effective patients.<BR>In 4 patients the Grade II b, residual surviving cancer cells were observed in the mandible.<BR>Accordingly, excision was needed in the area of radiologic features of mandibular infiltration. But it is considered that although the excision scope for the patient who has received the preoperative treatment is the same as that for the patient who has not, it is advantageous for the former patient that a wider safety region is obtained.
社団法人日本口腔外科学会の論文