エナメル上皮腫のPC-NA発現に関する免疫組織化学的検討

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Twenty-five ameloblastomas (19 primary and 6 recurrent) and 10 normal oral epithelia were evaluated by the streptavidin biotin immunoperioxidasemethod (SAB) to detect proliferating cell nuclear antigen (PCNA).<BR>PCNA-positive nuclei were identified in various intensities in both ameloblastomas and oral epithelia. In ameloblastomas, PCNA positive cells were found to be located mainly in the outer layer cells of the parenchymal nest of the tumor, while a few positive cells were observed in the inner cells, i. e. stellate cells and squamous cells. The average PCNA labelling index was 6.88% in ameloblastoma, and 8.6% in oral epithelium.<BR>PCNA labelling index was higher in recurrent cases than in primary cases. Expression of PCNA corresponded with histological growth patterns and type of outer layer cells, i. e. PCNA was detected in the basal cell type more than in the cuboidal cell and the columnar cell types. The above results suggest strong cell proliferation activity in the basal cell type.
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