顎骨骨肉腫の臨床的病理組織学的検索

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Clinical and liistopathological studies of four patients with ostcosarcoma of the jaws were reported. 1. Three patients were female and one was male, and their age ranged from 30 to 64 years. 2. One case had the lesion in the maxilla and the other in the mandible. Three cases with mandibular sarcoma complained of painless swelling, and one with maxillar sarcoma complained of paresthesia. 3. After the operation, three cases recurred, two of which showed metastasis. 4. Two of the patients had been diagnosed as osteosarcoma by preoperative biopsies but in the other two cases, malignancies were not found and fibrous dysplasia and ossifying fibroma were diagnosed respectively. 5. Examinations of the resected specimens revealed that the proliferative pattern of osteosarcoma was different depending on the area of the lesion. Central area was occupied with mature fibrous tissue and bone. Intermediate area was characterized by malignant osteoid and various features such as fibrosarcoma and benign tumorous lesion. In the marginal area, malignancy was not always found and extensive search seemed necessary for a correct diagnosis. Accordingly, it seemed important to take a biopsy specimen not only from the marginal edges but also from the deeper area.
社団法人日本口腔外科学会の論文