口腔癌における扁平上皮癌関連抗原 (SCC抗原) 量測定の臨床的意義

概要

論文の詳細を見る
The serum SCC antigen was examined in patients with malignant tumor of the oral cavity. It was evaluated whether the serum SCC antigen was useful in diagnosis of squamous cell carcinoma and the value of the serum SCC antigen was influenced by cancer therapy. Serum SCC antigen measurement was performed prior to therapy in 16 oral cancer patients. Ten patients (62.5%) showed values beyond cut-off level (2.0ng/ml). Twenty nine patients with benign tumor and non-neoplasic lesion were selected as control, and in 19 patients (65.5%) the value of the serum SCC antigen showed values beyond cut-off level. It seems that SCC antigen value measurement played a complementary role in diagnosis of oral squamous cell carcinoma. Patients who received surgery or chemotherapy showed immediate decrease of serum SCC antigen levels. In patients treated with a combination of radiation and chemotherapy, however, serum SCC antigen levels decreased later after treatment. The tissue SCC antigen values of 6 cases with oral cancer varied from 0.4 to 18.8ng/mg. Positive correation was found between the serum and the tissue SCC antigen value. In order to evaluate whether the serum SCC antigen is helpful in early detection of local recurrence or metastases, further study is necessary.