口蓋潰瘍を示したT細胞悪性リンパ腫 (いわゆる進行性鼻壊疽) の1例

概要

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The patient was a 36-year-old male, complaining of ulcer of the hard palate. A demarcated ulcer appeared in the middle area of the hard palate. The ulcer was covered with a necrotic tissue of yellowish white color. The shape of the ulcer was irregular and its size was 25mm in length and 18mm in width. The right nasal cavity was swollen edematously. X-ray films revealed that the nasal cavity, maxillary sinus and ethmoid sinus on the right side were filled with soft tissues. So-called progressive gangrenous rhinopathy was clinically suspected. The biopsy specimen from the ulcer of the palate showed malignant lymphoma and further examination using imrnuno-histochemical method disclosed T-cell lymphoma.<BR>Following chemotherapy (prednisolone and cyclophosphamide), radiation therapy (<SUP>60</SUP>Co-γ ray, 5, 100 cGy) was done. However, both therapies were ineffective and the patient died of hepatopathy 3 months after initiation of therapy.