Malodor of gauze tamponade applied to the postoperative defect of maxillary cancer: Prevention by topical use of clindamycin.

概要

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In an attempt to prevent bad breath produced from the gauze tamponade applied to the postoperative defect of maxillary cancer, the effect of topically by used clindamycin (CLDM) was evaluated by olfactory judgement and microbiological analysis in eight patients with bad breath. When a gauze tamponade containing azulene ointment and CLDM (120μg/g azulene) was applied, the bad odor was markedly improved or disappearedin all cases one week later. Concomitant with the improvement of bad breath, anaerobic microorganisms such as Bacteroides and Peptostreptococcus, which are considered to be involved in bad odor, also became undetectable. In addition, other gauze tamponades containing azulene ointment only, povidone iodine gel and oxytetracycline hydrochloride ointment were examined for their preventive effect on bad odor in one or two patients. Azulene ointment only and oxytetracycline hydrochloride ointment were ineffective or less effective on both bad ordor and bacterial growth, and povidone iodine gel showed adverse reactions such as bitterness, dryness of the mouth and mucosal irritation though the bad odor and bacterial growth were both inhibited.<BR>From these results, it was indicated that topical use of CLDM is very useful for prevention of bad odor of gauze tamponades in postoperative maxillary cancer patients.
社団法人日本口腔外科学会の論文