Di-(2-ethylhexyl) Phthalate投与ラットの脂質代謝変動に対する食餌性繊維の影響

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The effects of dietary fibers on the responses of hepatic and plasma lipids to feeding di-(2-ethylhexyl) phthalate (DEHP), the most commonly used plasticizer, were examined. Male young rats were fed a 20% casein diet containing 5% cellulose, CMC, pectin and chitosan with or without (control) addition of DEHP at a 0.5% level for 10 days. Feeding of DEHP caused a decrease in body weight gain and an increase in liver weight, regardless of the kind of dietary fibers. The extent of the decrease in weight gain was alleviated slightly by feeding pectin or chitosan. There were no significant differences in the extent of the increase in hepatic phospholipids and the elevation in the phosphatidylethanolamine/phosphatidylcholine ratio (0.47→0.68) by feeding DEHP among the four dietary fiber groups. A decrease in hepatic triglyceride was observed in rats fed DEHP and the extent of the decrease was much greater on a chitosan-DEHP group.
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