未知ビオチン活性物質の諸性質について(細菌類の蓄積するビオチン活性物質に関する研究-2-)

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It was found that two unknown biotin-vitamers were produced from dethiobiotin by a bacterial strain (N-4) isolated from soil. The unknown vitamers were purified by ion-exchange column and paper chromatography, and gel filtration. Amino acids in the purified vitamers were analyzed by paper chromatography and amino acid autoanalyzer. The results showed that the vitamer I contained an equal mole of dethiobiotin and α-alanine, and traces of valine, and the vitamer II contained an equal mole of dethiobiotin and serine, and a small amount of threonine. It was assumed that the vitamer I is a combined form of dethiobiotin with α-alanine, and the vitamer II is a combined form of dethiobiotin with serine. Distribution of the vitamers in some bacteria was also examined. The results showed that some bacteria isolated from soil produced the unknown vitamers accompanied with dethiobiotin and 7-keto-8-aminopelargonic acid in their culture media.
社団法人日本農芸化学会の論文