異時性六重複癌を有し, DICを起こして死亡した悪性黒色腫の剖検例

概要

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An autopsy case who died of multiple metastatic malignant melanoma with Disseminated intravascular coagulation (DIC) was reported. The patient was a 75-year-old femal, who noticed a black papule on her left cheek ten years before. It was resected with minimal margin and diagnosed as malignant melanoma. Two years after the resection, a mild blue subcutaneous nodule without pain appeared on the operated lesion and gradually elevated and enlarged to the thumb size. Therefore, in May, 1994, an extended resection was performed and she received chemotherapy in our clinic because of the diagnosis of local recurrence. After the operation, there was no sign of local recurrence or metastasis. In November, 1994, DIC suddenly occured. Although treated for the DIC, she died of multipe metastatic malignant melanoma with DIC. The patient had six primary tumors including malignant melanoma, double rectal adenocarcinomas, colon carcinoma and occult right thyroid papillaly adenocarcinoma.