Clinical evaluation of measurement of plasma antithrombin III, .ALPHA.2-plasmin inhibitor and plasminogen in various liver disease.

概要

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Plasma activity of antithrombin-III, α2-plasmin inhibitor, plasminogen were measured in 127 patients with histologically confirmed liver diseases by synthetic peptide substrate method. Patients with overt DIC were excluded from analysis.Plasma activity of three factors showed positive correlation with some parameters of liver function test which reflected protein synthetic ability of hepatocyte such as Ch-E, Alb, HPT and showed negative correlation with ICG R-15 value.These activity were found to be lower in accordance with progression of liver diseases.In conclusion, it is suggested that plasma activity of these factors well reflect not only severity and chronicity of liver disease, but also the liver function. Therefore measurement of these factors was useful to evaluate various liver disease.
財団法人日本消化器病学会の論文