:(1) Relationship Between Blood Biochemistry and Hepatic Morphology

概要

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The interrelations between blood biochemical findings including oral glucose tolerance and hepatic morphology were studied in 28 obese subjects (15 men, 13 women) showing more than 15% over ideal body weight without diabetes millitus and alcohol abuse.The liver histology in obese frequently showed fatty change (67.8%), and intranuclear vacuolization (46.4%), and less frequently exhibited periportal fibrosis (14.3%). The degree of hepatic fatty metamorphosis correlated well with the incidence of abnormal biochemical parameters (GOT, GPT, GOT/GPT ratio, LAP, γ-GTP, ChE), implying that abnormal liver sfunction in obese is due to hepatic steatosis. In the obese patients with fat accumulation from 1/3 to 2/3 of the liver lobule in biopsy specimens, 6 of 9 subjects (66.7%) had abnormal serum GPT activities, and 8 of 9 subjects (88.9%) had an elevation of serum transaminase activity with a greater rise in S-GPT than S-GOT. It is suggested that S-GPT and S-GOT/S-GPT ratio are sensitive indicators for fatty liver. And then it was shown that hepatic fatty change was promoted by hyperlipidemia and imparied glucose tolerance.