Immunohistological study of blood group antigens(Lea,Leb,X,Y) and CA19-9(sialylated-Lea) in gastric cancers and normal gastric tissues.

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The expression of blood group antigens and blood group related cancer-associated antigen (CA19-9, sialylated Lea) in gastric cancers and normal gastric tissues from 46 patients was analysed using an immunohistological method and a series of mouse monoclonal antibodies. Secretory status was determined by ELISA test on glycoproteins extracted from saliva of a selected number of the patients.In normal gastric tissues, type 1 (lea, Leb) was expressed in the surface epithelium, whereas type 2 (X, Y) was mainly detected in the deep glands.In gasric cancers, experssion and production of Lea and CA19-9 were greatly increased, especilly in secretors, and consistent distribution of Lea and CA19-9 were observed. X, Y as well as Leb were almost similar to normal tissues, but staining pattern of these antigens in cancers was classified as stromal type. High concentration of CA19-9 were found in sera from patients with advanced cancers.Study of those antigens in normal and malignant tissues from the same patient may provide us a clue to understand the anomalous expression in neoplasia.
財団法人日本消化器病学会の論文