STUDIES ON THE GLUCOSE INTOLERANCE IN ALCOHOLIC LIVER INJURY

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In order to study the glucose intolerance in alcoholic liver injury, the blood sugar and serum insulin (IRI) were determined during 50 g-oral glucose tolerance test (GTT) in 88 patients of alcoholic liver injury (alcoholic group) and 96 patients of nonalcoholic liver disease (non-alcoholic group). GTT was performed over one month after abstinence in all cases of alcohol group. In 25 patients of them, GTT was studied not only over one month after abstinence but also within one week after abstinence. Pancreozymin-secretin test was also performed in 65 patients of alcoholic group and 40 patients in non-alcoholic group.Within one week after abstinence, alcoholic group showed glucose intolerance more frequently than non-alcoholic group. After the abstinent period over one month, glucose intolerance was so remarkably improved in many cases of alcoholic group that there was not significant difference in blood sugar level during GTT between alcoholic group and nonalcoholic group. The level of 30'ΔIRI/ΔBS increased following abstinence comforming to the improvement of glucose intloerance or serum transaminase levels. However, except cirrhotic cases, the frequency of overt diabetic state was more common and the insulin secretory response was lower in alcoholic group than in nonalcoholic group. Moderate to severe pancreatic exocreine insufficiency was more frequently (16.1%) in non-cirrhotic alcoholic group than in non-cirrhotic non-alcoholic group and most of cases showing overt diabetes had moderate to severe pancreatic exocrine insufficiency in non-cirrhotic alcoholic group.From these results and our previous investigation, it is concluded that pancreatic disorder is important factor contributory to the glucose intolerance in non-cirrhotic alcoholic group. In cirrhotic alcoholic group, pancreatic exocreine function was almost normal and, therefore, we could not find the influence of pancreatic disorder on glucose tolerance.
財団法人日本消化器病学会の論文

STUDIES ON THE GLUCOSE INTOLERANCE IN ALCOHOLIC LIVER INJURY

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