14C-trioctanoin absorption test

概要

論文の詳細を見る
The absorption and transport of medium chain triglyceride (MCT) differ significantly from the absorption and transport of long chain triglyceride (LCT) such as triolein.In rat experiments, we have measured specific activity of 14CO2 in expired air after intragastric ingestion of 14C-trioctanoin to detect intestinal absorption of MCT. It has been cleared that the maximum specific activity and time course of specific activity of expired 14CO2 reflect well intestinal absorption of MCT and that this procedure is relatively simple and safe from the viewpoint of radiation to the patients since remaining of the radiation in a whole body is very small.Then we applied 14C-trioctanoin absorption test to the patients with malabsorption. It has been proved that the maximum specific activity of expired 14CO2 is lower in these patients than in control subjects. However, MCT was absorbed more easily than LCT in these patients since 14C-trioctanoin absorption test was not so impaired as 131I-triolein absorption test was.14C-trioctanoin absorption test is useful not only for the diagnosis of malabsorption syndrome but also for the indication of MCT therapy by combining with 131I-triolein absorption test.
財団法人日本消化器病学会の論文