Studies of the D-xylose absorption test:Part II. The influence of age on the D-xylose absorption test

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In the D-xylose absorption test, the amount or rate of D-xylose excreted in urine decreases with increasing age. It has been still debated whether its reduction is due to impaired intestinal absorption or to deterioration in renal function.We have investigated this problem by in vitro study using jejunal everted sacs of rats and clinical studies consisting of the D-xylose test (25g orally) to 44 subjects, the creatinine clearance to detect renal function in elderly, and the intravenous D-xylose test for correcting of the D-xylose absorption test.These studies show that the diminishing D-xylose excretion in elderly is due to the depression of renal function mainly glomerular filtration rather than to impaired intestinal absorption.Furthermore, we propose the corrected normal value of the D-xylose absorption test (25g orally) as follow; 5.9 to 9.1g (23.4 to 36.4%) in young (under 50 y.o.) and 3.7 to 6.0g (15.0 to 23.8%) in elderly (over 50 y.o.).
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