アテローム性動脈硬化症血管の脂質 (第2報) : 腹部大動脈脂質の透析と大動脈に存在する脂質-タンパク質複合体中の脂質

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In the former paper, it was pressumed that oxidized lipids form the complexes with proteins of arterial wall, and deposits of lipids then occurred around the complexes, cause atherosclerosis. Highly unsaturated acids in the lipids of arteries are concentrated in phospholipids. And also, more highly unsaturated acids are more easily oxidized. Therefore, in this case, oxidized lipid may be concentrated in the phospholipids contained in the lipids of atheroscleotic arteries. From this point of view, lipids of atherosclerotic abdominal aorta were dialysed to separate the residue (phospholipids concentrates) and the dialysate. And then these fatty acids were obtained. From ultraviolet and infrared spectra, compositions and properties of these fatty acids were made clear. It was ascertained that oxidized lipids were concentrated in the phospholipids contained in the lipids of the atherosclerotic aorta, and that the trans-trans conjugated diene hydroperoxide existed in the oxidized lipids.<BR>After extracting the lipids from the atherosclerotic aorta, further extraction was performed to obtain residue which then was hydrolysed with alkali, and the amount of fatty acids in the residue was estimated. Thus, it was demonstrated that the atherosclerotic aorta contained lipid-protein complexes. From the infrared spectrum it became clear that oxidized lipids containing trans isomers existed in the lipids of the lipid-protein complexes.
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