癌組織の脂質 (第2報) : 気管支癌および癌性胸水の脂質

概要

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In the previous paper, authors presumed that the cancerous cell might be produced, probably changing the status of cell-division if the oxidized lipids would form the complexes with nucleoproteins.<BR>There has been the suggestion that all carcinogenic compounds are able to concern themselves in reactions leading to produce free radicals. Besides, it has been recognized that lipids is oxidized through catalysis by the free radicals.<BR>But it can be hardly assumed that cancer of lung may be generated by taking oxidized lipids directly through trachea. If the substances containing free radicals such as cigarette smoke enter into the lung, lipids of the tissue may be oxidized with free radicals as catalysts. In such a case, cancerous tissue in lung may contain oxidized lipids. From this point of view, lipids were extracted from the tissue of bronchial carcinoma, a kind of cancer of lung, and fatty acid methyl esters of the lipids prepared. All procedures were performed at room temperature under the stream of nitrogen. The methyl esters of fatty acids of lipids from cancerous pleural fluids were also obtained. Then acids compositions were calculated from ultraviolet spectrum. It was made clear that trans-trans or cis-trans conjugated diene hydroperoxide was contained in the methyl esters of fatty acids obtained from the lipids of all sumples from the infrared spectrum.
社団法人日本油化学会の論文