油脂化学の立場からみたアテローム性動脈硬化症発生原因についての一仮説 : アテローム性動脈硬化症血管の脂質 (第3報)

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In atherosclerosis, the most popular type of arterosclerosis, the deposit of cholesterol or cholesterol esters in the artery were present, but the cause of the deposit is still obscure. The lipids in the plasma are present as lipo-proteins. Generally, this combination of lipids and proteins is not strong. However, lipids, in which oxidized unsaturated fatty acids are present, and proteins react to form the lipid-protein complexes, with the strong combinning forces between the both undecomposed by the solvent extraction. If oxidized lipids form the complex with the proteins of the artery, it may be presumed that cholesterol and fatty acid cholesterol esters may be deposited around the complex. It was previously shown by the authors that trans-trans conjugated diene hydroperoxides are present in the lipids of atherosclerotic breast aorta. As the cause of atherosclerosis outbreak, the author presents a hypothesis that, “the oxidized fats form the complex with the proteins in aorta vessel, and then the lipids, such as cholesterol or cholesterol esters, are deposited around the complex in the artery” (written as (A) in the undergoing). It was previously shown by the authors study that oxidized lipids are concentrated in the phospholipids of atherosclerosic aorta lipids, that they contain trans-traps conjugated diene hydroperoxides, that the lipid-protein complexes are present in atherosclerosic abdominal aorta, and that oxidized lipids containing traps isomers are present in the lipids combining with the aorta proteins. These facts are evidence of (A). Athero sclerosis broke out in the aorta of the rabbit by feeding it with the yolk of egg or with the brain of cattle. This can be explained by (A). It was reported that the deposit of lipids in artery has relation to lipo proteins in plasma. This can be understood by (A). Though Japanese take small amounts of fat, many are suffering from atherosclerosis. This cause can be explained by (A). Atherosclerosis also breakes out by taking a large amount of fat or cholesterol, by removing thyroid gland, and by feeding the food absence vitamin B<SUB>6</SUB>. These causes can be also understood by (A). By dosing vitamin G, pantothenic acid, or a large amount of proteins, atherosclerosis outbreak is restrained. This can be explained by (A).<BR>Thus the hypothesis (A) may be valuable to afford general understanding of atherosclerosis outbreak.
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