レプトスピラ症患者における間接血球凝集反応の検討

概要

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The indirect hemagglutination (HA) test using tanned formalinized sheep erythrocytes sensitized with deoxycholate-extracted antigens of Leptospira was evaluated in the diagnosis of leptospirosis.The results of studies using five strains of Leptospira and sera from cases of human leptospirosis representing three different serotypes showed the genus-specificity of this test.Titers obtained by the HA test using hebdomadis antigen and the microscopic agglutination (MA) test using homologous antigens in 52 sera from patients with leptospirosis showed fairly good correlation. However, four sera with MA titers of 1:30 or less gave high HA titers of 1:12, 800 to 1:409, 600.HA titers in 15 out of 16 sera obtained 15 to 21 days after onset ranged from 1:25, 600 to 1:409, 600. Out of 52 sera from healthy individuals (MA titer:<1:30), only one gave a HA titer of more than 1:800.
日本衛生学会の論文