トリフェニル錫の好中球機能-とくにスーパーオキサイド(O^⨪_2)生成および脱顆粒に及ぼす影響

概要

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Brief treatment (3 min at 37℃) of human neutrophils with triphenyltin chloride (TPTC1) resulted in a dose-dependent inhibition of superoxide (O^⨪_2) production stimulated by concanavalin A+cytochalasin D. It was considered from the following findings that the inhibition may be caused by some functional disorders of neutrophils: 1) O^⨪_2 generated by xanthine oxidase-acetaldehyde system was not inhibited by TPTC1. 2) There was no change in cell viability after treatment with TPTC1. When the other phenyltin compounds were examined, the relative potencies of inhibitory effect were shown to be in the order of TPTCl > diphenyltin dichloride > phenyltin trichloride > tetraphenyltin on a molar basis. Lysosomal enzyme release caused by neutrophils stimulated by N-formyl-methionyl-leucyl-phenylalanine (FMLP) was also inhibited by TPTCl. These results suggest that TPTCl inhibits the common pathway(s) of the two stimulus responses.
社団法人日本産業衛生学会の論文
1984-03-20