Studies on Antianaemic Ingredients of the Liver-IX:Alleviative Effect on Promin-induced Anaemia due to Folic Acid and to a Combination of Folic Acid with Vitamin B12 or a Furified Liver Fraction

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In a preceding paper1), it has been reported that ?? purified fraction of whale liver at a 5-g fresh liver level was effective to alleviate promin-induced anaemia, and that its effect was not apparently due to vitamin B12 from a 5-g portion of fresh liver. Experiments have been carried out to see whether promin-induced anaemia be alleviated by administration of folic acid. The interrelationships between folic acid, vitamin B12 and a purified liver fraction have also been studied. The results obtained can be summarized as follows: 1. Folic acid was not effective when administered, whether orally or injected, at a 10-mg level per 100g body-weight of albino rat (Fig. 1). 2. The purified liver fraction at its ineffective level, i.e., a 40-mg level (equivalent to 2.0g fresh liver) showed a marked effect when supplemented with 1.5mg of folic acid. A combination of a 1.5-microgram level of vitamin B12 with 1.5mg of folic acid was somwhat effective, though each level alone has been confirmed to be ineffective (Fig. 2). 3. Data presented here suggest that the purified fraction of whale liver contains apparently an unidentified antianaemic factor which is responsible for alleviating the promin-induced anaemia.
社団法人日本水産学会の論文