Protein kinase C in regenerating rat liver.

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Serial changes of protein kinase C (PK-C) activity and 12-o-tetradecanoyl phorbol-13-acetate (TPA) binding activity in regenerating rat liver were studied with special reference to DNA synthesis. Effect of TPA administration on DNA synthesis was also studied. DNA synthesis did not increase at 12 hours and reached a peak value at 24 hours after partial hepatectomy (HPX). PK-C activity in soluble fraction of regenerating liver decreased at 24 hours (p<0.01) and increased at 48 hours (p<0.05) after HPX. TPA binding activity in soluble fraction increased at 48 hours (p<0.05), but no significant change of TPA binding activity was observed in precipitate fraction of the partial hepatectomized liver. Intraperitoneal administration of TPA at the time of HPX caused a significant reduction of DNA synthesis at 24 hours (p<0.01) after HPX.<BR>These observations suggest that PK-C may have an inhibitory effect on the regeneration of rat liver.
社団法人日本肝臓学会の論文