実験的急性肝不全における網内系賦活剤の予防効果に関する研究

概要

論文の詳細を見る
We investigated the influence of galactosamine (Gal N) or Gal N and Endotoxin model in rats in which the RES was normal or stimulated by OK-432. Results, 1) The mortality of the rats administrated Gal N 1.2g/kg or Gal 0.5g/kg and Endotoxin 0.5mg/kg was 100%. On the other hand, the RES stimulated rats by OK-432 were survived more than one month after administration of Gal N or Gal N and Endotoxins. 2) The pretreatment of OK-432 inhibited the increase of S-GOT, S-GPT and bilirubin concentrations in serum after 24 hours and so on. 3) Histological studies revealed the massive liver necrosis in Gal N treated rats at 48 hours after Gal N administration. On the other hand, pretreatment of rats with OK-432 revealed only focal necrosis, but not massive necrosis. 4) The Gal N liver injury was inhibited by the pretreatment of rat with OK-432.
社団法人日本肝臓学会の論文