Proliferation activities of intrasplenic hepatocytes and the influence of hepatotrophic factors.

概要

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Proliferating activities of syngeneic donor hepatocytes in the rat spleens were assessed by DNA-synthesizing S phase cells after pulse-labeling monoclonal antibody to BrdU. Furthermore, the influence of hepatotrophic factors on the intrasplenic hepatocytes were also investigated in the rat with partial hepatectomy or with portacaval shunt.<BR>In this studies, we confirmed that inoculated hepatocytes possessed the auto-regulated proliferating activities, and they were accelerated by the hepatectomy of the host liver but no noted change in the intrasplenic hepatocytes was observed in the rats with portacaval shunt.<BR>Our investigations may offer significant approaches to the evaluation of cytokinetic behaviors of donor hepatocytes and regenerating hepatocytes.
社団法人日本肝臓学会の論文