A case report of 19-year-old HB virus carrier with chronic .DELTA. infection for 10 years died of acute hepatic failure.

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19-year-old male HB virus carrier was admitted to our hospital because of fulminant hepatic failure. He was gotten diagnosis of nephrotic syndrome when he was 3 year old. Adrenocorticosteroid had been administerd from 5 years-old to 3 months prior to the admission. He'd been diagnosed of early liver cirrhosis by liver biopsy 2 months prior to the admission. Although plasma exchange and glucagon-insulin therapy were performed, severe hepatic failure progressed. He died on 10th hospital day.<BR>In this case δ antibody was highly positive and re-examination proved persistant δ infection for 10 years. δ antigen was found in autopsy liver tissue. There was no evidence of super infection of another hepatitis virus. Hepatic failure in this case may be induced by acute exaggration of chronic δ infection.
社団法人日本肝臓学会の論文