無症候性原発性胆汁性肝硬変の肝外門脈シャント

概要

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Extrahepatic portovenous shunts were demonstrated in 4 of the 5 patients with asymptomatic primary biliary eirrhosis (a-PBC) (3 gastro-renal shunts, and one each of spleno-renal and retroperitoneal shunts). We found no statistical differences in the results through comparative studies between a-PBC patients and control subjects in regard to portal venous blood flow (PVf). Portal venous pressure was within normal limits in 4 of the 5 studied patients. A presinusoidal block was histopathologically recognized in 2 of the three without portal hypertension, while a sinusoidal change was extensively noted in the remainder with portal hypertension. In conclusion, the extrahepatic portovenous shunt is formed in the very early stage of PBC along with other histopathological changes.
社団法人日本肝臓学会の論文