各種肝疾患における血清中Thrombomodulinの臨床的意義-急性肝不全を中心として-

概要

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We measured serum level of thrombomOdulin (TM), which is known to be a maker of injured vascular endothelial cell, in several liver diseases. In the patients of acute liver failure, significant increase of serum level of TM was observed, as compared with acute hepatitis. Although it has been noted that there is a tendency of correlation between serum level of TM and creatinine, remarkable increase of serum TM in acute liver failure was observed in the patients Without renal failure. These results suggest that a increase of serum level of TM predict the development of with acute liver failure. This observation indicated possible involvement of intravascular coagulation in pathogenesis of acute liver failure.