インターフェロン治療を契機として急性憎悪をきたし,その後自己抗体の陽転をみた非B非C型慢性活動性肝炎の1例

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A 54-year-old man with latent autoimmune hepatitis who presented acute excerbation with severe jaundice following the treatment of recombinant alpha interferon (α-IFN) is reported. s-GPT and bilirubin increased after the initiation of treatment which temporaril ydiscontinued after 28 days. Maximum level of s-GPT and total bilirubin attained 1278IU/l and 29.3mg/dl respectively, in spite of the discontinuance of α-IFN administration. s-GPT and bilirubin subsequently showed rapid decreases, and histological findings after the pause in treatment were worse than those obtained before treatment. And then, autoantibodies turned positive after the pause in treatment. The cause of these hepatic disorders induced by IFN administration is not clear, we think that the latent autoimmune hepatitis was influenced by the IFN. The present case suggests that studies regarding the complications of treatment with IFN are necessary.