TREATMENT OF GALLSTONE WITH URSODEOXYCHOLIC ACID:Lipid and Bile acid Composition in Bile

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Concentration and composition of lipid and bile acid in bile were studied in 33 patients with gallstone before and after 1 to 18 months of oral therapy with ursodeoxycholic acid (UDCA, 450mg per day). A molar percentage ratio of bile acids plus lecithin to cholesterol was remarkable elevated after the administration of UDCA. This change was associated with a reduction off cholesterol excretion in bile and an increase of biliary bile acid concentration. UDCA was detected in bile of all cases with an average of 28.8% of total biliary bile acids after the treatment.In this study, the administration of UDCA did not significantly increase the concentration of lithocholic acid in bile. The data suggest that UDCA lowers lithogenicity of bile and UDCA seems to be effective and safe for the treatment of gallstone.
財団法人日本消化器病学会の論文