RadioimmunoassayによるHBe抗原・HBe抗体の測定

概要

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Serum samples from 152 HBsAg carriers were assayed for HBeAg and HBeAb by the radioimmunoassay. The radioimmunoassay was approximately 100-fold more sensitive than immunodiffusion for HBeAg and approximately 8 fold more sensitive than immunodiffusion for HBeAb. By radioimmunoassay only 9.9% of the tested cases were negative for both HBeAg nor HBeAb. In asymptomatic HBsAg carrier group, the freqrency of HBeAb was 71.4%. In chronic hepatitis, it is obvious that HBeAg positivity was significantly more frequent in chronic active hapatitis than chronic inactive hepatitis. The overall frequency of HBeAg and HBeAb coexist in serum was 0.6%. In 3 cases of chronic hepatitis, both HBeAg and HBeAb were detected by radiaimmunoassay before the conversion from HBeAg positivity to HBeAb positivity. There was a positive correlatian between HBeAg titers and S/N ratios of diluted serum (1:20 and 1:00).
社団法人日本肝臓学会の論文