A SUGGESTION ON THE MECHANISM HOW ELECTRIC CURRENT EXCITES THE NERVOUS SYSTEM
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1. If the faradization of a certain strength and duration was applied to the motor cortex of a dog, the epileptic seizure was produced which continued after the cessation of the application, and when the motor cortex was excised, the attack was suddenly ceased.2. When a minute quantity of nicotine, picrotoxine, pentamethylentetrazol in its diluted solution was introduced into the grey matter of the motor area of a dog, the epileptic seizure was produced and continued, and as soon as when the site of its application was excised, the attack was suddenly ceased.3. Acetylcholine in its rather high concentration which was applied to the motor area could produce the epileptic fit as the above chemicals in dogs as well as in human beings.4. Sodium glutamate if pure in its appropriate concentration also could produce from the motor cortex the fit of epileptic seizure in dogs as well as in human beings, but when it was mixed with proteinoids, those motor action was inhibited.5. When sodium glutamate was not pure, it was inactive in the above motor effect, but if it was treated for a few second in vitro by the electric current, direct or induced, it was suddenly disinhibited and produces the motor effect. The sodium glutamate was the only substance which would be activated by current in vitro.6. A model experiment was introduced and discussed by the author which suggested how electric current excited the motor nerve cells of extrapyramidal system. At the same time, a hypothesis on aetiological origin of epilepsy was offered.
- The Keio Journal of Medicineの論文
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